Revitalizing Reproduction: Coenzyme Q10 and its Impact on Fertility

When it comes to female and male fertility, the health and quality of egg and sperm cells play a crucial role. These cells require a significant amount of energy to develop and are susceptible to oxidative damage. One key nutrient that has gained attention in recent years for its potential benefits in supporting fertility is Coenzyme Q10 (CoQ10). In this article, I will review what CoQ10 is, how it works, and the potential benefits it may offer for both male and female fertility. Let’s dive in shall we!

What is CoQ10?

CoQ10 is a naturally occurring biomolecule in the human body, and it is present in every cell. It exists in two common forms: ubiquinone and ubiquinol. CoQ10 acts as a potent antioxidant and plays a critical role in cellular energy generation through the electron transport chain. 

CoQ10 and Female Fertility

CoQ10 has been studied for its potential benefits in enhancing egg quality and female fertility. As a powerful antioxidant, CoQ10 helps protect the eggs from oxidative damage. Several studies have also shown that CoQ10 supplementation can improve mitochondrial cellular energy production which is crucial for egg maturation. Both of these factors improve egg quality, and potentially fertility outcomes (1) (2) (3) (4).

Additionally, CoQ10 has been extensively studied in the assisted reproduction technology world, and has been shown to be beneficial in cases of PCOS (polycystic ovary syndrome) and poor ovarian reserve (5). For instance, co-administration of Coenzyme Q10 and Letrozole (which is an ovulation induction medication) versus Letrozole alone improves ovarian response, ovulation rates, endometrial thickness and pregnancy rates in PCOS patients in comparison to Letrozole alone (6). Furthermore, pretreatment with Coenzyme Q10 in women with low ovarian reserve undergoing IVF or ICSI has been shown to improve response to ovarian stimulation medications, increase the number of eggs retrieved, increase fertilization rates, and increase the number of high quality embryos (7). 

CoQ10 and Male Fertility

CoQ10 is not only beneficial for female fertility but also for male fertility. Sperm cells also require a significant amount of energy to develop and are susceptible to oxidative damage. CoQ10's role as an antioxidant helps protect sperm cells from oxidative stress, which can negatively impact sperm health. Studies have shown that CoQ10 supplementation can improve sperm parameters, including sperm count, motility, and morphology.. These improvements may increase the chances of successful fertilization and pregnancy (8) (9) (10) (11).

Dosage and Considerations

When considering CoQ10 supplementation, it is important to consult with a healthcare provider, especially if you are currently taking any medications. The dosage of CoQ10 for fertility purposes may vary, but generally, a daily dosage of 200-600 mg is recommended depending on the underlying cause of your fertility challenges.

Conclusion

Coenzyme Q10 (CoQ10) has emerged as a promising nutrient for improving fertility outcomes. Its powerful antioxidant properties and role in cellular energy generation make it a valuable addition to the fertility journey for both men and women. CoQ10 supplementation may help support egg and sperm quality, and enhance the chances of a successful pregnancy. If you would like to learn more about whether CoQ10 supplementation is right for you, please don’t hesitate to book a naturopathic appointment with me at Juniper Family Health. I’m here to help!

In health and happiness,

Dr. Meghan van Drimmelen, ND | Naturopath Victoria BC

References:

1. Co-Enzyme Q10 Supplementation Rescues Cumulus Cells Dysfunction in a Maternal Aging Model

2. Coenzyme Q10 ameliorates the quality of postovulatory aged oocytes by suppressing DNA damage and apoptosis

3. Can Coenzyme Q10 supplementation protect the ovarian reserve against oxidative damage?

4. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging

5. Does coenzyme Q10 supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials

6. Coenzyme q10 and letrozole versus letrozole alone for ovulation induction in polycystic ovary syndrome

7. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial

8. The impact of two doses of coenzyme Q10 on semen parameters and antioxidant status in men with idiopathic oligoasthenoteratozoospermia

9. Antioxidant supplements and semen parameters: An evidence based review

10.  Effect of Ubiquinol Therapy on Sperm Parameters and Serum Testosterone Levels in Oligoasthenozoospermic Infertile Men

11. Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study